Prior to her marriage, Marianne worked for a Middle East Embassy as the Program Director for Cultural Affairs.  She oversaw the admittance and study programs for 2,500 graduate students studying in universities and colleges throughout the United States.  While still at the Embassy she was offered a position with the Office of Protocol at the State Department.  During the interim period of accepting the position at the State Department, she met Dean and they married.

In 2019, while in London for the premier of “Cliffs of Freedom”, a feature film that Marianne wrote and produced, she was introduced to Prince Charles, now King Charles, and members of the Greek Royal Family.  At that time Marianne learned of the work that Prince’s Trust International, now known as the King’s Trust International, was doing in Greece.  Wanting to help promote  and advance this important work, she became “Grand Benefactor” in 2020 having contributed through these last five years several million dollars reaching 15,265 children and young people across Greece, Kenya and Rwanda. The Trust supports education, job opportunities, and helps young people to have the ability to start their own businesses among many other things.

“I wanted to help families who were not able to offer these advantages to their children and to honor Dean’s parents, who loved their homeland, but immigrated to America because it was their only hope to offer their children a better life, not available in the village of Dean’s birth.  It has been an honor and a privilege for me and my family to be a part of this unique organization”.

Marianne heads the Metropoulos Family Foundation, which is a member of the “Giving Pledge”.  The Foundation also supports cancer research in Epigenetics and advancing TCR Cellular Immunotherapies for solid cancers at Memorial Sloan Kettering Cancer Center which is truly groundbreaking in finding a cure for certain cancers.  The Cleveland Clinic, Paul Newman’s “Hole in the Wall” camps for critically ill children suffering from cancer, Wounded Warriors, St. Jude’s Children’s Hospital, among many others.  The Foundation is also supporting “Big Dog Ranch Rescue” which was founded in 2008 and has saved and adopted out 60,000 dogs and is a “no kill” dog rescue.

The Foundation recently launched at Babson College in Boston, the C. Dean Metropoulos Institute for Entrepreneurship and Technology Center.  As Babson has been recognized for over a century as one of the top entrepreneurial schools in the U.S., Dean felt that given the incredible momentum of AI, young entrepreneurs must embrace, empower and control AI as it truly redefines and challenges our world going forward.